Fri Dec 08 2023

23 articles - From Friday Dec 01 2023 to Friday Dec 08 2023

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…


Meta-analysis

meta-analyses and systematic reviews

Inflamm Bowel Dis

Incidence and Prevalence of Primary Sclerosing Cholangitis: A Meta-analysis of Population-based Studies.

Both the prevalence and incidence of primary sclerosing cholangitis is low in the general population. Future studies on the incidence and prevalence of primary sclerosing cholangitis in the general population should be directed at Asia, Africa, and Latin America to allow for a more robust assessment of the global epidemiology of primary sclerosing cholangitis.

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Pancreatology

K-ras gene mutation analysis to diagnosis pancreatic adenocarcinoma from endoscopic ultrasound-guided tissue acquisition; a systematic review and meta-analysis.

K-ras gene mutation analysis in combination with to pathological diagnosis of EUS-TA increases the accuracy of differential diagnosis of PDAC.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

Associations of dietary patterns between age 9 and 24 months with risk of celiac disease autoimmunity and celiac disease among children at increased risk.

Dietary patterns in early childhood are associated with risk of CDA and celiac disease in genetically predisposed children, independent of gluten intake.

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Bioavailability and daily requirement of vitamin B12 in adult humans: an observational study of its colonic absorption and daily excretion as measured by [13C]-cyanocobalamin kinetics.

Background Clinical and biochemical vitamin B intakes.

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Effect of an Asian-adapted Mediterranean diet and pentadecanoic acid on fatty liver disease: The TANGO randomized controlled trial.

Mild weight loss induced by a Mediterranean-like diet adapted for Asians has multiple beneficial health effects in women with NAFLD. C15 0 supplementation lowers LDL-cholesterol and may cause beneficial shifts in gut microbiome. Registration clinicaltrials.gov, NCT05259475.

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Glycemic and sleep effects of daytime compared to overnight infusions of home parenteral nutrition in adults with short bowel syndrome: a quasi-experimental pilot trial.

Daytime HPN was feasible and safe in adults with SBS, and compared to overnight HPN, improved subjective sleep without increasing 24-hour glucose levels.

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Healthy dietary patterns, genetic risk and gastrointestinal cancer incident risk: a large-scale prospective cohort study.

Adherence to DASH and hPDI were associated with a lower risk of some gastrointestinal cancers, and these two dietary patterns may partly compensate for genetic predispositions to cancer. Our results support the development of precision medicine strategies that consider both dietary patterns and genetics to improve gastrointestinal health.

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Lifetime dairy product consumption and breast cancer risk: a prospective cohort study by tumor subtypes.

These findings suggest that overall dairy consumption was not associated with risk of breast cancer. However, heterogeneity was observed for type of dairy food, period of life, and tumor subtypes.

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Phytosterol Intake and Risk of Coronary Heart Disease: Results from Three Prospective Cohort Studies.

Higher long-term intake of total and major subtypes of phytosterols may be associated with a modest reduction in CHD risk, displaying a non-linear relationship that appeared to plateau at moderate intake levels. The role of phytosterols in preventing CHD warrants further investigation.

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Prebiotics increase iron absorption and reduce the adverse effects of iron on the gut microbiome and inflammation: a randomized controlled trial using iron stable isotopes in Kenyan infants.

Adding prebiotics to iron-fortified infant cereal increases iron absorption and reduces the adverse effects of iron on the gut microbiome and inflammation in Kenyan infants.

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Prevalence of the Metabolic Syndrome by Household Food Insecurity Status in the United States Adolescent Population, 2001-2020: A Cross-Sectional Study.

Using the most current NHANES data, the estimated prevalence of MetS in US adolescents was slightly higher among those from FI households. However, after adjusting for potential confounders, the relationship between household FI and MetS was non-significant, highlighting the complexity of factors contributing to MetS in this population. Hispanic adolescents share a disproportionate burden of MetS compared to their non-Hispanic counterparts.

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Red meat intake and risk of type 2 diabetes in a prospective cohort study of United States females and males.

Our study supports current dietary recommendations for limiting consumption of red meat intake and emphasizes the importance of different alternative sources of protein for T2D prevention.

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Relative validity of habitual sugar and low/no-calorie sweetener consumption assessed by FFQ, multiple 24-h dietary recalls and urinary biomarkers: an observational study within the SWEET project.

The validity of the FFQ against 24hRs for the assessment of sugars and LNCSB ranged from moderate to good. Comparing self-reports and urine excretions showed moderate agreement, but highlighted an important underestimation of LNCS exposure using the self-reports.

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Inflamm Bowel Dis

Altered Bile Acid and Pouch Microbiota Composition in Patients With Chronic Pouchitis.

Pouch microbiota a- and ß-diversity differed among patients with normal pouch, chronic pouchitis, and chronic pouchitis/primary sclerosing cholangitis. Lithocholic acid level and primary to secondary bile acid ratio were highly associated with pouch microbiota richness, structure, and composition. These findings emphasize the associations between pouch microbiota and bile acid composition in dysbiosis and altered metabolism, suggesting that secondary bile acids are decreased in chronic pouchitis.

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J Crohns Colitis

Biologic therapy for inflammatory bowel disease: Real-world comparative effectiveness and impact of drug sequencing in 13,222 patients within the UK IBD BioResource.

We provide real-world evidence to guide biologic selection and sequencing in a range of common scenarios. Our findings challenge current guidelines regarding drug selection after loss of response to first anti-TNF.

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Impact of Maternal Smoking, Offspring Smoking, and Genetic Susceptibility on Crohn's Disease and Ulcerative Colitis.

Our prospective cohort study provides evidence that MSDP increases the risk of CD in adult offspring, whereas no evidence supports their causal association. Additionally, smoking and genetic susceptibility had a numerically amplified effect with MSDP on CD and UC, but the interaction lacked statistical significance.

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The clinical relevance of an inflamed appendix in Crohn's disease.

The current study could not confirm a different prognosis for CD patients with and without an inflamed appendix. In contrast, in patients with a previous appendectomy a trend was seen towards increased postoperative recurrence, which might be related to the higher incidence of penetrating disease.

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Pancreas

Real-World Patient Experience With Pancreatic Enzyme Replacement Therapy in the Treatment of Exocrine Pancreatic Insufficiency.

This study reveals potential barriers to effective treatment of EPI with PERT, including lack of patient education, mainly how and when to take PERT, gaps in appropriate dosing, and lack of patient follow-up. Continued focus on patient and provider education is essential to address these gaps and optimize the treatment of EPI.

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Pancreatology

Evaluation of pancreatic chymotrypsin activity for on-site prediction of clinically relevant postoperative pancreatic fistula.

Measurement of pancreatic chymotrypsin activity enabled accurate and rapid prediction of CR-POPF after pancreaticoduodenectomy. This can help surgeons to implement appropriate drain management at the patient's bedside without delay.

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Novel treatment system using endoscopic ultrasound-guided high-intensity focused ultrasound: A proof-of-concept study.

The concept of transluminal HIFU ablation using novel EUS-HIFU system was proved in a porcine animal model. This novel treatment system has great potential for future cancer treatment although further investigation in more animals and different organs are warranted.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Nutrition and risk of celiac disease - you are what you (wh)eat.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

J Crohns Colitis

Filgotinib for the Treatment of Refractory Collagenous Colitis.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

The value of ethnographic studies for making inferences about the nature of the human Paleolithic diet: comments on Lieberman et al. (2023).

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